Sample requirements

DNA sample requirements for sequencing

Minimum input, concentration, purity and integrity for whole-genome and exome sequencing, targeted panels and HLA typing. Every value is given here in full, not locked in a PDF.

← All sample submission guidelines

Genomics platform

DNA sequencing service sample requirements

DNA can be submitted in DNase-free water, elution buffer, or 10mM Tris pH 8.0. Samples should be RNase-treated, show no degradation or contamination, and have an OD260/280 as close to 1.8–2.0 as possible. Ship with ice packs. These requirements apply to our Genomics platform.

Concentration note. Values below assume fluorometry (Picogreen/Qubit/RiboGreen). If you're relying on spectrophotometry (e.g. Nanodrop) instead, increase concentrations by roughly 2×.
Illumina services: DNA5 services · view full table +
ServiceSample typeRecommended quantityMinimum quantityMinimum concentration
Whole Genome SequencingGenomic DNA≥ 500 ng200 ng10 ng/µL
Whole Genome Sequencing (PCR-free)Genomic DNA≥ 1 µg500 ng20 ng/µL
Whole Exome SequencingGenomic DNA≥ 500 ng100 ng10 ng/µL
16S / 18S / ITS SequencingGenomic DNA≥ 100 ng10 ng1 ng/µL
HLA TypingGenomic DNA≥ 200 ng
Cells, PBMC≥ 1×10⁶
Blood≥ 1 mL
Buccal swab2 swabs
Dried blood spot (DBS)2 completely filled spots, 10 mm diameter each

The 16S/18S/ITS Sequencing row above is delivered through our Metagenomics & Microbiome platform.

Not sure which service fits?

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